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Concomitant use of dihydrocodeine and sedative medicines including benzodiazepines or related drugs may possibly bring about sedation, respiratory depression, coma and Loss of life. Because of these risks, concomitant prescribing with these sedative medicines need to be reserved for patients for whom alternative treatment solutions are impossible.

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In Japan, dihydrocodeine is available without a prescription; used in cough medicines which include New Bron Resolution-ACE. Dihydrocodeine is utilized being an antitussive in several products like a Dextromethorphan alternative. Medicines in Japan which contain dihydrocodeine are coupled with caffeine to offset the sedative effects and discourage

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